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The biggest revolution in the aesthetic world in recent years has been to “stimulate” the skin from the inside instead of “filling” it from the outside. Now everyone wants collagen, everyone is after biostimulation. However, when you look at the menu, you may get confused: Crystal Filler, Smart Filler, Youth Vaccine, Salmon DNA... They all claim to produce collagen. So, which one is the one you need? Differences between collagen stimulating treatments What are they?
Istanbul Nisantasi Medlook Polyclinic we simplify this complex chemistry lesson for you. In fact, all biostimulants are messengers that send a message to the skin: “There is damage here, repair it!”. But the language and speed of each messenger (molecule) is different. In this guide, we discuss the main players in the market (CaHA, PLLA, PCL) and explain which molecule solves which problem with scientific data.
1. Player: Calcium Hydroxyapatite (CaHA) - “The Strong Architect”
On the market Crystal Filling or Radiesse known as bone. It contains the same mineral as our bone structure.
- Character: Hard, strong and lifting (Lifting).
- Mission: It provides both skeletal support (chin, cheekbones) and tightens the skin.
- Duration of Effect: 18-24 Months.
- For Who: For those who have sagging on their face, whose jaw line becomes dull and bone resorption begins.
- Difference: It gives instant results. There is no need to wait. Structure does not make payments by necessity.
Player 2: Polylactic Acid (PLLA) - “The Patient Artist”
On the market Sculptra known as a "suture". It is actually a substance used in surgical threads and dissolves over time.
- Character: Slow, gentle and spreading.
- Mission: Rather than volumizing, it improves the quality of the skin and thickens thinned skin.
- Duration of Effect: 24 Months and over (Longest-acting group).
- For Who: For people with a thin face, paper-thin skin and sunken temples.
- Difference: You will not see the result immediately. The effect starts in the 3rd month. It requires patience but the result is very natural.
Player 3: Polycaprolactone (PCL) - “Smart Filler”
On the market Ellanse is known as.
- Character: It's both a filler and a stimulant.
- Mission: It gives instant volume like classic fillers and produces collagen for a long time like PLLA.
- Duration of Effect: Depending on the product selected, it may take 1, 2, 3 or 4 years.
- For Who: For those who want long-lasting and voluminous results in one session.
- Difference: You can choose the duration of persistence (with S, M, L, E forms).
Player 4: Hybrid Fillers (CaHA + HA) - “Modern Synthesis”
On the market Harmonyca is known as It combines the strength of Calcium with the moisture of Hyaluronic Acid.
- Character: Versatile. Both lifting and moisture.
- Mission: It removes the dullness of the skin while lifting the face up.
- Duration of Effect: 18-24 Months.
- Difference: It combines two effects (volume + repair) in one injector. Detailed information Click here for more information.
Comparative Summary Table: Which Molecule?
Technical summary to make your decision easier:
| Criteria | CaHA (Crystal) | PLLA (Sculptra) | Hybrid (Harmonyca) |
|---|---|---|---|
| Lifting Power | Very High | Middle | High |
| Volume Effect | Middle | Low (Increases over time) | High (Instant) |
| Seeing Results | Now. | 3 Months Later | Now. |
| Number of Sessions | Usually 1 | Usually 2-3 | Usually 1 |
Which is Safer?
All are FDA approved and biocompatible. However, there are small differences in their safety profiles:
- Nodule Risk: In PLLA (Sculptra) application, there may be a risk of clumping if the patient does not massage at home. This risk is lower with CaHA and Hybrid fillers and no massage is required.
- Meltability: None of them (except the HA part of the Hybrid) can be dissolved with enzymes. Therefore, the physician's experience is more important than the choice of product.
Medlook Nisantasi Approach: Personalized Cocktail
We do not stick to a single product. We can apply PLLA to the temple area of your face (for volume), CaHA to the jawline (for sharpness) and Hybrid Filler to the cheeks (for brightness). Biostimulant There is no “best product” in the world, there is a “product best suited to the problem”.
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Frequently Asked Questions (FAQ)
Technically, yes, it regenerates cells. However, it does not build a "tissue scaffold" as strong as the molecules mentioned above (CaHA, PLLA). Salmon DNA mostly polishes the skin surface, it does not recover sagging. It is in the mesotherapy group.
No, it is not. PCL is a biodegradable substance. When it expires (1-4 years), it is completely converted into water and carbon dioxide and excreted from the body. Only your own collagen tissue is left behind.
Generally, the costs of PCL (Smart Fillers) and PLLA (Sculptra) may be slightly higher than conventional fillers and CaHA. However, considering their duration of permanence (2-4 years), their annual cost is lower.
PLLA for protection in the 30s, Hybrid or CaHA for lifting in the 40s, PCL or CaHA for volume and structuring in the 50s.
Appointment and Contact
Let's skip chemistry and focus on biology. We can't know by heart what your skin needs, but we can analyze it. Medlook Polyclinic’s center in Nişantaşı, Istanbul, let's decipher the language of your skin and choose the most suitable “Molecule of Youth” together. Conscious choice is the best aesthetic result.
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