Biostimulants

Don't “Stuff” Your Face, “Wake Up” Your Skin”

For many years, the aesthetic world perceived the signs of aging only as “filling the gaps”. If there were wrinkles, fillers were applied, if there was volume loss, the face was inflated. However, this approach has sometimes resulted in “artificial” and “look-alike” faces. Today Dr. Handan Yavuz Medlook Polyclinic under the leadership of Medlook Polyclinic, the understanding of aesthetics has completely changed: The aim is no longer just to fill the gap, but to trigger the skin's capacity to repair itself (regeneration).

This is where Biostimulants is entering. This technology, sometimes known as “Smart Filler”, “Mineral Vaccine” or “Liquid Rope” among the public; Instead of giving the skin a passive volume, it stimulates the skin's biological mechanisms to produce its own **Type 1 Collagen**. The result? A skin that does not swell, does not change its expression, but tightens day by day, gains lifting effect and improves its quality.

What is Biostimulant? What is the Difference from Classical Filling?

Understanding this distinction is key to choosing the right treatment. Classic hyaluronic acid fillers do a “mechanical” job; they retain water and give volume immediately. Biostimulants do a “biological” job.

Biostimulant Technologies We Use in Medlook

Biostimulants create different biological effects according to their ingredients. Dr. Handan Yavuz selects one or a combination of the following ingredients according to your skin structure and aging type:

1. Calcium Hydroxyapatite (CaHA) - Mineral Strength

They are calcium microspheres that are naturally present in our bone and tooth structure. When injected under the skin, these micro-crystals act as a scaffold. Fibroblasts surround this scaffold and begin to weave strong collagen fibers. It is the gold standard especially in jawline definition and hand back rejuvenation.

2. Polycaprolactone (PCL) - Smart Polymers

PCL, the raw material of medical dissolving sewing threads, creates a powerful biostimulating effect when applied to the skin. While improving skin quality, it supports collagen production, which offers long-term (1-4 years) permanence.

3. Polylactic Acid (PLLA)

It is an agent that gradually volumizes and repairs the deep layers of the skin. It is especially preferred for sunken cheeks and general loss of elasticity.

Why Biostimulant Application?

If you say “I want a change in my face but no one will know what I have done”, biostimulants are designed for you.

The Medlook Difference Holistic Rejuvenation Protocol

If the foundation of a building is rotten, painting the walls is useless. At Medlook, we don't see biostimulant administration as just an injection. We support the process from the inside to maximize collagen production:

• IV Vitamin C Supplementation: Vitamin C is essential for collagen synthesis. We apply it together with the procedure Intravenous Vitamin C, biyostimülanın verimini %50 oranında artırır.
• Amino Acid Supplement: We recommend nutritional regulation so that the amino acids (glycine, proline), which are the raw materials of collagen, are sufficient in the body.

Who is Suitable for Biostimulants?

• Those with the Onset of Prolapse: Those who lose skin elasticity from their mid-30s onwards.
• Those Who Do Not Want Filling “I don't want my face to swell, I just want it to recover”.
• Neck and Hand Rejuvenation: It is the most effective solution not only for the face but also for neck wrinkles and aging hands.
• Male Patients: It is ideal for men who want to rejuvenate while maintaining masculine lines without creating a feminine appearance (rounded lines).

Frequently Asked Questions

When will I see the result?

This is a “process” treatment. Although a slight fullness is seen immediately after the procedure, the real “Wow Effect” occurs in the 2nd and 3rd months when collagen production peaks. Every day your skin gets better and better.

How many sessions do you need?

Depending on the age and damage of the skin, 1 to 3 sessions at 4-6 week intervals are usually recommended. The effect lasts for 1.5 - 2 years.

Can it be combined with classical filling?

Absolutely. With Medlook's “Hybrid Approach”, a perfect balance is achieved by applying classical fillers to places where bone support is required, such as the cheekbones, and biostimulants to the cheek gaps and jaw line.

Does it cause nodules or lumps?

This risk is minimal when the correct dilution rate and the correct layer (deep dermis or over bone) is applied. Dr. Handan Yavuz's anatomical experience and use of FDA approved products guarantee your safety.

Istanbul Biostimulant (Smart Filling) Prices 2026

Biostimulant applications are priced according to the type of material used (CaHA, PCL) and the number of vials (syringes) required. The width of the areas such as the face, neck or on the hands determines the cost. You are invited to our clinic for a personalized treatment plan and clear price information.