How Many Days Does Botox Set and What Are The Factors That Reduce Its Effect?
Botox (Botulinum Toxin), arguably the most popular procedure in the field of medical aesthetics, which has been safely applied in the medical world for years, continues to be our number one solution in wrinkle treatment. The first question our patients ask us when they look in the mirror after leaving Medlook Polyclinic with a slight excitement is always the following: “How many days does Botox set, when will my wrinkles disappear?”
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ToggleIf your face has been filled (e.g. for a natural volume french lip filler), you see the effect in the mirror that very second. However, Botox is not a gel that physically fills, but a medical protein that commands the muscles. Therefore, it requires a biological time for its effect to start.
Botox Effect and Sitting Schedule
When Botox reaches the muscle into which it is injected, it interrupts the communication between the nerve endings and the muscle, preventing excessive contraction of the muscle. This communication interruption is a cellular process that “takes time”. (For one of the areas where this effect is best observed wrinkles around the eyes at an early age you can read our article).
Here is the biological adventure of Botox day by day:
- Day 1 - Day 3: After 48-72 hours after the procedure, you will start to feel little by little that your muscles are not contracting as strongly as before (for example, you cannot frown comfortably). The lines begin to soften.
- Day 7 - 10: It is the period approaching the maximum effect of Botox. Wrinkles are largely lightened and the skin looks taut and bright (Botox glow).
- Day 14 - 15: Botox is fully established. Artık ilacın kas üzerindeki hakimiyeti %100’e ulaşmıştır. Bu sebeple tüm botoks kontrol randevularını 15. güne veririz. Asimetri veya rötuş ihtiyacı ancak bu gün tam olarak anlaşılabilir.
Factors Reducing the Effect and Permanence of Botox
Botox procedure lasts for an average of 4 to 6 months. However, in some of our patients, we can observe that this period ends in a much shorter time (2-3 months) or that the botox “does not hold”. The main reasons for this are:
| Factor | Negative Effect of Botox |
|---|---|
| Excessive Heat and Baths | Staying in a sauna, hot water or under the intense sun in the early days causes the medicine to lose its effect (break down) by damaging the protein. |
| Intense Sport (Exertion) | In professional athletes (especially weight lifters) with a very high metabolic rate, Botox dissolves 2 times faster than normal. |
| Frequent Injections | Having Botox once a month or too often without waiting 6 months causes the body to develop ‘antibodies’ (resistance) against this protein and the drug does not work. |
| B12 and Vitamin Deficiencies | In terms of longevity, extremely low levels of zinc and B12 in the body make it difficult for Botox enzymes to bind to muscle tissue. |
Accurate knowledge of muscle anatomy and the use of original FDA-approved drugs with appropriate storage conditions (cold chain) are the most important medical standards that determine the permanence of the procedure. World Health Organization (WHO) According to the norms, these drugs must be reconstituted and administered by physicians in hospital/clinic settings.
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Frequently Asked Questions (FAQ)
Yes, we especially ask you to make a lot of facial expressions (frowning, smiling) for the first few hours after the procedure. Because exercising the muscle allows the injected botox drug to be distributed faster and more evenly to the muscle cells.
For the first 4-6 hours after the procedure, you should never lie down, lie down or tilt your head forward (to prevent the drug from descending into the eyelids by gravity). However, you only need to choose a high pillow for sleeping at night and do not sleep face down for the first night.
Absolutely not. This is an urban legend. Botox rests your muscles and prevents the formation of new wrinkles during this 4-6 month period. When the effect wears off, your face just goes back to the 'old' way it was before you had the procedure; it never gets worse.
Appointment and Contact
At Medlook, each application is planned individually after a detailed facial analysis. For more information about Botox applications, please contact us at you can contact.









