Radiesse® (Calcium Hydroxyapatite):
Lifting Effect and “Gold Standard” in Skin Quality”

There are hundreds of filler brands in aesthetic medicine, but very few are considered a “category creator” (Game Changer). Radiesse®, is the world's first and most established Calcium Hydroxyapatite (CaHA) filler with FDA (US Food and Drug Administration) approval. This technology has proven its safety and effectiveness with more than 10 million injectors used worldwide, Dr. Handan Yavuz‘Radiesse is one of the most frequently used “Structural Repair” agents in Nişantaşı Medlook Polyclinic. The biggest feature that distinguishes Radiesse from others is its versatile structure. When used as a concentrate, it can be used on a hard material such as bone. Lifting and when thinned in special ratios (Hyperdilute Radiesse), it wraps the skin like velvet. Skin Quality increases. It is not just a space filler; it is a powerful biological stimulus that gives your skin back the elasticity and collagen it has lost.

Radiesse® Technology: The Invisible Architecture Under the Skin

Radiesse has a unique formulation: %30 Kalsiyum Hidroksiapatit (CaHA) mikro-kürecikleri and %70 CMC (Karboksimetil Selüloz) Jel carrier.

1. Instant V-Effect

The CMC gel in its content has a high viscosity. In this way, the moment it is injected into the jawline or cheekbone, it defies gravity and lifts the face (Lift). It instantly transforms the sagging facial oval (U-shape) into an inverted triangle (V-shape), the symbol of youth.

2. Long-term Skeleton Construction

While the CMC gel is slowly absorbed by the body, the CaHA microspheres remain fixed under the skin. These spheres act as a “scaffold” for the skin's fibroblast cells. The body surrounds this scaffold with newly produced collagen and elastin fibers. The result: Structural well-being that lasts for 18-24 months.

Medlook's Special Technique: Hyperdilute Radiesse®

The great magic of Radiesse is that its form is interchangeable. Dr. Handan Yavuz uses this product not only to give volume, but also to “iron” the skin. Here it is Hyperdilute Technique it comes into play.

In this technique, Radiesse is diluted with sterile saline and lidocaine in specific ratios (1:1, 1:2 or 1:3). It is no longer a “filler” but a “mesotherapy” agent that spreads under the skin. With this technique

Neck Wrinkles Transverse lines and relaxation in the neck (Venus rings) are treated.
Decollete Rejuvenation: Sleep lines and sun damage are repaired.
Arm and Abdominal Prolapse: The crepe paper-like thin skin on the inner arm and abdomen is thickened.
Acne Scars Common pitted scars on the face are filled underneath and the skin surface is smoothed.

Information: Hyperdilute application does not volumize or inflate the face. It only improves the quality, thickness and elasticity of the skin.

Why Choose Radiesse®?

This prestigious FDA-approved brand offers our patients the following privileges:

Triple Effect

While many fillers only do one thing, Radiesse solves three problems at once:

Fills It gives volume to sunken areas.
Lifts (Lift): Recovers sagging skin.
New ones: Triggers collagen and elastin production in the skin.

Ideal Choice for Men

Unlike women, male facial anatomy requires sharper contours and less subcutaneous fat. While hyaluronic acid fillers can soften and feminize the male face; Radiesse with its water-repellent structure masculine, clear and strong creates an expression.

Leader in Hand Rejuvenation

Radiesse is the first filler to receive FDA approval to treat volume loss in the dorsum of the hand. It rejuvenates old-looking, veined and bony hands by 10 years in a single session. Thanks to its opaque structure, it hides the veins.

In which areas is Radiesse® used?

Radiesse works best in “still” and “bony” areas of the face:

Cheekbones To move the face up.
Nasolabial Furrows To open the deep lines on the side of the nose.
Marionette Lines: To erase the sad expression at the corner of the mouth.
Jawline: To create a sharp profile.
Chin Tip (Chin): To bring the back jaw forward and provide projection.
Hands: For overhand rejuvenation.

Note: Radiesse cannot be applied on the lips and under the eyes (tear trough).

The Medlook Difference: Combination of Radiesse and IV Support

Radiesse is a powerful collagen stimulator (biostimulant). However, in order for your body to respond to this stimulus, its stores must be full. At Medlook Polyclinic, we do not see Radiesse application as an isolated procedure.

1. IV (Intravenous) Collagen Precursors

Immediately after or before Radiesse application IV Vitamin C, Glutathione and Amino Acids içeren özel serumlar öneriyoruz. C vitamini, kolajen üretiminin “kofaktörüdür”; yani o olmadan Radiesse’in uyardığı hücreler kaliteli kolajen üretemez. Bu kombinasyon, işlemin verimini ve kalıcılığını %40-50 oranında artırır.

2. Non-Traumatic Application with Cannula

Dr. Handan Yavuz, Radiesse uygulamasında %90 oranında ucu küt kanül kullanır. Bu teknik:

Eliminates the risk of vascular damage.
Minimizes bruising and edema.
It allows the product to spread more homogeneously under the tissue.

Implementation Process and Recovery

The Radiesse® (+) Plus series contains lidocaine (local anesthetic). This makes the procedure very comfortable.

Duration: The procedure takes 30 minutes on average.
Social Life You can return to work immediately. A slight edema or tenderness may last 2-3 days.
Conclusion: The volume effect is immediate. The increase in skin quality (brightness and tightening) starts from the 1st month and reaches its peak in the 3rd month.
Persistence: Although it varies from person to person, the average is 18 months or more.

Is Radiesse® Safe?

Radiesse is a biocompatible (body-friendly) and biodegradable (dissolves over time) material. Like permanent fillings, it does not stay in the body forever, but is excreted over time through natural metabolic pathways.

When having an X-ray or CT scan, it is sufficient to tell your doctor that you have Radiesse filling, because the calcium content may be visible on imaging, but it is not harmful to health. The most important safety factor is the experience of the practitioner. At Medlook, all applications are performed under the supervision of a physician and under sterile conditions.

Istanbul Radiesse® Filler Prices 2026

Radiesse prices are determined by the amount of injector used (1.5 cc or 3 cc) and the width of the application area. Usually 2 injectors may be required for face lifting and 1-2 injectors may be required for hand rejuvenation. In Hyperdilute applications, planning is completely personalized.

Frequently Asked Questions About Radiesse®

Can Radiesse be melted?

Hyaluronic acid cannot be dissolved with the enzyme “Hyaluronidase” like fillers. However, in cases of overcorrection, agents such as sodium thiosulfate or dilution with saline can be tried. Since it is difficult to return, it must be done in experienced hands such as Dr. Handan Yavuz.

Will it clump on my face?

When applied at the right depth and with the right massage, the risk of clumping is very low. Radiesse is a homogeneous gel.

From what age is it done?

It can be safely applied as a preventive measure when collagen loss begins in the 30s (Hyperdilute) and to replace volume loss after the 40s (Lifting).

Is Crystal Filler and Radiesse the same thing?

Description. “Crystal Filler” or “Mineral Filler” is the colloquial name for Radiesse's ingredient Calcium Hydroxyapatite (CaHA). Radiesse is the leading brand in this technology.

Radiesse