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PLLA (Poly-L-Lactic Acid):
“Seeds of Youth” Under the Skin”
What is PLLA (Poly-L-L-Lactic Acid)? How Does It Work?
Poly-L-Lactic Acid is a biocompatible and biodegradable (completely absorbed by the body) synthetic substance that has been used safely in medicine (dissolving sutures, orthopedic implants) for over 30 years. Its use for aesthetic purposes is based on the principle of activating the basic building blocks of the skin.
PLLA's 3-Phase Working Principle
- 1st Placement (October): PLLA micro-particles are mixed with sterile water and injected into the deep layers of the skin or over the bone membrane. In the first days, there is a fullness due to the effect of the water, but this water is absorbed by the body within a few days and the face returns to its former state. At this stage, our patients may think “Has the effect worn off?”. However, the real process is just beginning.
- 2. Activation (Alert): The PLLA particles left behind after the water is absorbed gently stimulate fibroblast cells (collagen factories). The body uses a dense layer of collagen to envelop these particles. Neocollajenesis (new collagen formation) starts the process.
- 3. Regeneration (Harvest): After about 4-6 weeks, the PLLA particles slowly dissolve into carbon dioxide and water and are eliminated from the body, leaving behind a strong collagen network that is your own tissue. This network lifts the skin (lifting), tightens and repairs volume loss with natural texture.
To summarize: PLLA does not “give you fish”, it teaches your skin to “fish (produce collagen)”.
Why Should You Prefer PLLA, Not Classic Filling?
PLLA Biostimulants offer unique advantages for patients who are patient and want “permanent and natural improvement” rather than “quick change”.
⏳ Long Lasting Results (2+ Years)
While classical hyaluronic acid fillers last an average of 6-12 months, the results obtained with PLLA last longer than 25 months. Because the volume obtained is not an artificial gel, but living tissue produced by the body itself.
🚫 No “Pillow Face” Syndrome
PLLA does not retain water. Therefore, your face does not look edematous, swollen or “made”. Your mimics do not change, your expression does not deteriorate. You just look more rested and firmer.
📈 Gradual and Secret Change
The change is spread over time (3-4 months). In this way, the people around you do not realize that you have had a procedure done on your face, they just say “You look very good lately, you have become younger”. Ideal for those who want privacy in social life.
🏗️ Structural Lifting
It does not only fill wrinkles; it provides a strong lifting effect by lifting the sagging skin from the temples and jaw line upwards.
Where can PLLA be applied?
Poly-L-Lactic Acid has revolutionized not only facial rejuvenation but also body contouring.
- Temporal Collapse To fill the temples and raise the eyebrows, which have sunken in with age.
- Cheek and Midface: To lift the cheeks that sag with gravity and restore the “V” shape.
- Marionette (Sad Mouth) Lines: To structurally repair the deep grooves from the edge of the mouth down to the chin.
- Jawline: To pick up skin laxity and create a sharp line.
- Neck and Decolletage: To thicken and tighten thin, crepe paper-like skin.
- Hand Rejuvenation To hide the veined and bony appearance and to plump the skin of the hands.
- Body (Butt and Cellulite): Butt lift (BBL alternative) and to correct deep cellulite dimples (Body Sculpting).
Medlook Difference: Maximize Collagen Production with a Holistic Approach
PLLA application orders the skin to “produce collagen”. However, if your body lacks the “raw material” to fulfill this order, the result will be limited. It is not enough to send an architect to a construction site; you also need bricks, cement and iron. At Medlook Polyclinic, we support PLLA treatment with holistic protocols.
1. IV (Intravenous) Vitamin C Supplementation
Collagen synthesis cannot occur without vitamin C. We apply it simultaneously with the procedure or as a follow-up High Dose IV Vitamin C, increases the speed at which fibroblasts work and improves the quality of the collagen produced.
2. Nutrition and Supplementation Plan
Our Dietitian Uzm. Dyt. Sernaz Cakir Ercil, supports your treatment process at home with a nutrition list rich in Copper, Zinc and Amino Acids (Proline, Glycine), which are essential for collagen production.
3. Safe Application Technique (Cannula Use)
PLLA is a material that should not be smuggled into the vein. Dr. Handan Yavuz minimizes the risk of vascular damage, bruising and complications by using the blunt “Cannula” technique instead of sharp needles.
The Golden Rule for Successful Treatment: 5-5-5 Massage
In PLLA biostimulant application, the patient's home care is as critical as the doctor's success. In order to distribute the particles homogeneously (evenly) under the skin and to prevent clumping 5-5-5 Rule must be implemented:
“For 5 DAYS after the procedure,
Five times a day,
5 MINUTES at a time
The application area should be massaged hard.”
This massage ensures that the “seeds of youth” are evenly distributed in the soil (skin).
Who is an Ideal Candidate for PLLA Biostimulants?
- Those with a weak and sunken face: It is the best option to restore volume in people with an athletic background or those who have lost a lot of weight through dieting and whose face has “sunken in”.
- Deteriorating Skin Quality: People with fine wrinkles, thin and loose skin (loss of elasticity).
- Those who do not compromise on naturalness: “Those who say, ”Let my face not change, just go back to the way it was.".
- Long-Term Thinkers: Busy business people who do not want to chase filling appointments every 6 months.
- 40 years and over: It is the most powerful support in the age group where collagen production drops dramatically.
The Truth About Side Effects and Nodule Risk
The most feared issue in online research about PLLA is the formation of “nodules” (hardness under the skin). This was a problem seen in older generation application techniques.
Applied in Medlook Modern PLLA Protocol this risk is minimized:
- The product is prepared 24-48 hours before treatment to ensure complete hydration.
- Higher dilution ratios (dilution) are used.
- It is not applied to the very superficial layers of the skin, but to the deep dermis or bone.
With these precautions and patient compliance with the 5-5-5 massage, PLLA is an extremely safe and comfortable procedure.
Give Your Skin the Value It Deserves
Book your appointment now for healthy and radiant skin.
Istanbul PLLA Filling Prices 2026
PLLA Filler (Liquid Rope) applications are priced according to the number of vials used.
Although there is a general approach of 1 vial for every 10 years of age (e.g. 2 sessions for 40 years of age, total 2-3 vials), the most accurate planning is based on age and skin damage. Thoughts is determined by.
Meet your most powerful ally in the battle against time. Give your skin the “structural” support it deserves.
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